2016年4月4日 星期一

104-02-Week 5 Still Alice, Alzheimer’s disease, Julianne Moore

In her Best Actress acceptance speech, Julianne Moore expressed gratitude that her film “Still Alice” could raise awareness about early-onset Alzheimer’s disease.(Getty Images/Craig Sjodin)
Julianne Moore took home one of the night’s top honors at Sunday’s Academy Awards, winning Best Actress for her role as a professor with early-onset Alzheimer’s disease inStill Alice. In the film, Moore portrays a highly respected Columbia University linguistics expert who starts to get lost on her regular runs and, ironically, begins to grasp for words.
"I’m so happy, I’m thrilled actually, that we were able to hopefully shine a light on Alzheimer’s disease," Moore said in her acceptance speech for the Academy Award. In post-Oscar press interviews, she added, “I like stories about real people, and real relationships, and real families, and that’s what I respond to, and this movie had all of those things in it. It’s about a real issue.”
Early-onset Alzheimer’s is defined as Alzheimer’s disease that affects a person younger than 65. The Alzheimer’s Association says that up to 5 percent of Americans with the disease have early-onset Alzheimer’s.
The symptoms are very similar between younger and older people with Alzhemer’s disease, says James Leverenz, MD, director of the Cleveland Center for Brain Health atCleveland Clinic’s Neurological Institute. “There has been a general sense that the younger onsets have a more aggressive and rapidly progressing disease than the older onsets, but every patient is a little bit different,” he tells Yahoo Health.
So-called “normal” memory loss, which can begin in the mid-30s, is characterized by a slowing in the retrieval of information, Leverenz says. It might be more difficult to come up with words and names, but you can still learn and hold onto new memories, he explains.
Alzheimer’s disease, on the other hand, involves difficulties learning and remembering new things. People with the condition “may be having a conversation over dinner and then an hour or two later they don’t remember that conversation,” Leverenz says. “In younger-onset patients, we also sometimes see problems with planning, organizing, and multitasking. A lot of people are still working, and they notice that at work they’re struggling to keep up because they don’t have the speed and organization that they used to have.” (For more telltale symptoms, the Alzheimer’s Association offers a guideto 10 early signs of the disease.)
The challenge of coping with a new sense of self, portrayed in Still Alice, is a common experience for many patients, Leverenz confirms. It’s normal to feel frustrated that things that used to be easy and second nature are now difficult. 
“There can be a real loss of self,” he says. “I’ve had a lot of patients say to me, ‘This is something I always used to be able to do, in fact I took a lot of pride in my memory, and now it’s not a strength, it’s a weakness.”
Especially for people with early-onset Alzheimer’s disease, a proper diagnosis is important because many other conditions — such as hormone and nutritional deficiencies — can trigger similar symptoms, Leverenz explains. The Alzheimer’s Association recommends having an evaluation with a doctor who specializes in the condition.

104-02-Week 4 Hong Kong, bookseller, missing(disappear)

A second of five Hong Kong booksellers detained on the Chinese mainland has returned home, according to police.
Cheung Chi-ping, who went missing in October after a trip to visit relatives in Shenzhen, was released just two days after his boss Lui Por, a general manager at the Mighty Current publishing house, was also allowed to return to Hong Kong.
In both cases the Hong Kong police released a statement confirming the men were home. According to the police both men said they did not need further assistance from the government or the police force.
Mighty Currents prints titles highly critical of the Communist party and the Chinese government, and, in the weekend before the men started to disappear, had been printing volumes that attacked Chinese president Xi Jinping’s private life.
Gui Minhai and Lee Bo, the owners and managers of the publishing house and its attached bookshop, Causeway Bay Bookstore, and another employee Lam Wing-kee, remain missing.
Gui, a Swedish national, disappeared in October after a holiday in Thailand. He reappeared in January in a tearful televised “confession” in which he said he had voluntarily returned to China out of remorse over a hit-and-run in 2004.
Lee Bo, a British national feared to have been kidnapped on Hong Kong soil, has also appeared in a televised interview where he said he had returned to China “of his own accord” in order to help with “an investigation”, and that he was renouncing his British citizenship. He reportedly met with Hong Kong police last week in an undisclosed location and told them he did not need any help.
The three clerks of the Mighty Current publishing house and Causeway Bay Bookstore had also appeared on a televised interview, where they said they had been detained for “illegal book trading” in the mainland, supposedly admitting to having delivered about 4000 books to China since 2014 without a licence.
Bao Pu, an independent publisher in Hong Kong, said he believed with this gesture “the Chinese authorities want to minimise the impact of the bookstore event, and sweep everything under the carpet as quickly as they possibly can”.

http://www.theguardian.com/world/2016/mar/06/second-missing-hong-kong-bookseller-returns-from-china